課程名稱 |
藥品動態學 Pharmacokinetics |
開課學期 |
102-1 |
授課對象 |
醫學院 藥學系 |
授課教師 |
林君榮 |
課號 |
PHARM7005 |
課程識別碼 |
423 M0400 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期一8,9(15:30~17:20) |
上課地點 |
基醫504 |
備註 |
與余秀瑛、胡幼圃合開 總人數上限:30人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1021advancepk2013 |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
Advance Pharmacokinetics is a continued course for Biopharmaceutics and Pharmacokinetics. The major purpose of this course is to teach students how to solve pharmacokinetic or pharmacodynamic problems using mathematical approaches. Some of the information and concepts from mathematics and elementary pharmacokinetics will be reviewed or developed as needed, but the balance of prerequisite material will be the student’s responsibility. Readings and homework will be assigned, or may be suggested to improve the learning efficiency of students. |
課程目標 |
Several topics will be introduced and elaborated in this course: Compartment Models; Pharmacokinetic / Pharmacodynamic (PK/PD) models; Physiological models; Nonlinear Pharmacokinetics; Absorption kinetics; Noncompartmental analysis;
Population pharmacokinetics. |
課程要求 |
It is important to develop an independent ability to construct pharmacokinetic (PK) and/or pharmacodynamic (PD) models corresponding to situations encountered in research and clinical study.
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
Gibaldi and Perrier, Pharmacokinetics, 1982
Wagner, Fundamental of clinical pharmacokinetics, 1975
Rowland and Tozer, Clinical pharmacokinetics, 1995
Guterman and Nitecki, Differential equations, 1992
In addition to the recommended texts above, readings from other books, review articles or the primary scientific literature may be assigned or recommended by each instructor. Some of the faculty may also provide handout notes as a guide or supplement to their lectures.
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評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第1週 |
9/09 |
Clearance Concepts |
第2週 |
9/16 |
Physiological Pharmacokinetic Models |
第3週 |
9/23 |
Compartment Models |
第4週 |
9/30 |
PK/PD I |
第5週 |
10/07 |
PK/PD II |
第6週 |
10/14 |
Discussion |
第7週 |
10/21 |
Tissue distribution and protein binding |
第8週 |
10/28 |
溫書假 |
第9週 |
11/04 |
期中考 |
第10週 |
11/11 |
PK/PD of antibiotics |
第11週 |
11/18 |
調整放假 (胡幼圃教授) |
第12週 |
11/25 |
Effect of a drug on serum bilirubin level and risk |
第13週 |
12/02 |
Elucidate contradictory clinical reports on
metabolic rate of a drug |
第14週 |
12/09 |
Nonlinear Pharmacokinetics- I&II [16:00-18:30] |
第15週 |
12/16 |
Noncompartmental Analysis
Absorption kinetics- I [16:00-18:30] |
第16週 |
12/23 |
Absorption kinetics- II&III [16:00-18:30] |
第17週 |
12/30 |
溫書假 |
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